Accounting for the shared variance between CUDs and other SUDs, there remained significant associations between CUD comorbidity and psychosis and nicotine dependence, suggesting that these clinical features may represent more robust and unique correlates of CUD comorbidity in BD. In contrast, non-significant results from the multivariate models suggested that associations between CUD comorbidity and manic/mixed symptom polarity may be better accounted for by more general substance use behaviors that frequently co-occur with CUDs, and that shared variance with other comorbid SUDs may also better explain the associations between CUD comorbidity and greater likelihood of AUDs in BD. To our knowledge, this is the first study to demonstrate such effects, and will therefore require replication in other samples.
