No brain regions were discovered for typical alcohol use after correction for multiple comparisons (DPW-PRS, Supplemental Results). Several nominally significant associations arose in analyses for both PAU and DPW (Table 1). Notably, DPW-PRS showed a nominal association with left frontal pole volume (Table 1). Given that typical and problematic alcohol are genetically correlated (SNP-rg=0.78) (12), such consistency is unsurprising. A regression with PAU-PRS and DPW-PRS entered simultaneously show that this finding is driven primarily by PAU-PRS (Table 2).
