in the model where the SNP predicted the addiction-rf alone relative to the SNP predicting the indicators themselves was considered a significant Q-SNP above genome-wide significance (i.e. Q p < 5e-8). SNPs with significant Q-SNP statistics were removed from the addiction-rf summary statistics for all post-hoc analyses, including fine-mapping, gene-based tests, transcriptome-wide association analyses, LD score genetic correlations and polygenic risk score analyses.
