Q-SNP analysis also identified several SNPs that appeared to be specific to a single substance. However, as Q-SNP cannot be used for precise identification of substance-specific (trait-specific) SNPs, we relied on ASSET analyses (with a 1-sided p-value), to identify the subset of SNPs with effects (at genome-wide significance, p<5e-8) limited to only 1 SUD-related trait (e.g., PAU-specific). It is worth noting that the ASSET analysis used to determine specific SNPSs is the same analysis that went in the cross-ancestry results, except pleotropic loci were retained for the cross-ancestry analysis and specific SNPs for the analysis described here.
