Pathway analysis using a pre-ranked enrichment analysis revealed significant enrichment of dorsal striatum DE genes for several GO terms and Hallmark gene-sets. Genes in the CN were found to be related to cilia- and microtubule-associated GO-terms, while none of the Hallmark gene-sets was significantly enriched. GO-term and Hallmark gene-set analysis in PUT samples showed enrichment for immune processes, such as “acute inflammatory response to antigenic stimuli” (pFDR = 0.006) and “adaptive immune response” (pFDR = 0.006). In the VS the most significantly enriched GO-terms were also related to cilia and microtubules, as well as antigen processing. All GO-terms and Hallmark gene-set with FDR < 0.10 are listed in Supplementary Tables S5 (CN), S6 (PUT), and S7 (VS).
