to be associated with reduced alpha power (Ponomareva, Korovaitseva, & Rogaev, 2008). Most importantly, this association has been observed in healthy young adults (Lee et al., 2012). A similar association has been reported (Ponomareva et al., 2013) between reduced alpha power and a variant of the CLU gene (encoding glycoprotein clusterin, or apolipoprotein J), which also confers risk for cognitive impairment in later life (Golenkina et al., 2010; Harold et al., 2009; Lambert et al., 2009). Although it was once thought that LVA was due to a single dominant gene (Anokhin et al., 1992; Vogel, 1986), this hypothesis has not been borne out. Recently, associations have been reported in women between LVA and the Val158/Met polymorphism in COMT (Enoch, Xu, Ferro, Harris, & Goldman, 2003) as well as a polymorphism in the GABAB receptor gene, independent of gender (Winterer et al., 2003). Other candidate gene findings exist (Loo et al., 2010), although involving a different type of polymorphism than a SNP, which is the focus of the present investigation.
