An online version of the MetaGAP calculator can be found at www.devlaming.eu. This calculator computes the theoretical power per trait-affecting haplotype block, the power to detect at least one of these blocks, and the expected number of (a) independent hits, (b) true positives, (c) false positives, (d) false negatives, and (e) true negatives, for a meta-analysis of GWAS results from C studies. In addition, it provides the expected R2 of a PGS for a hold-out sample, including all GWAS SNPs, with SNP weights based on the meta-analysis of the GWAS results from C studies. Calculations are based on the generic expressions for GWAS power derived in S1 Derivations and PGS R2 derived in S2 Derivations.
