The calculator assumes a quantitative trait. Users need to specify either the average sample size per study or the sample size of each study separately. In addition, users need to specify either the average within-study SNP heritability or the SNP heritability per study. The SNP heritability in the hold-out sample also needs to be provided. Users are required to enter the effective number of causal SNPs and the effective number of SNPs in total. The calculator assumes a fixed CGR between all pairs of studies included in the meta-analysis and a fixed CGR between the hold-out sample and each study in the meta-analysis. Hence, one needs to specify two CGR values: one for the CGR within the set of meta-analysis studies and one to specify the genetic overlap between the hold-out sample and the meta-analysis studies.
