A risk score calculated from the top 50% of SNPs in the HA Finnish-only meta-analysis accounted for 0.28% of the variance in HA in the QIMR sample (P=0.007); however, this result was not significant after correction for multiple testing (six thresholds and four scales=24 tests). The top 10% of SNPs in the RD and P Finnish-only meta-analysis accounted for 0.15% (P=0.052) and 0.17% (P=0.04) of the variance in RD and P in the QIMR sample, respectively. Using all SNPs in the Finnish-only meta-analysis of NS accounted for 0.059% (P=0.22) of the variance in NS in the QIMR sample. Other SNP thresholds resulted in less of the variance in the QIMR sample being accounted for by the risk score (Supplemental Table S4).
