PAC values during the movement were calculated as zMVL as described in the materials and methods. We examined whether PAC averaged over the whole movement period (3-s time series) of each different condition (state-related PAC) was modulated by different tasks in patients and controls. First, zMVL values were averaged across the pairwise matrix of ICA components (n × n components), for each subject in each condition, as described in materials and methods, Calculation of movement-related PAC. To reduce the number of factors, we first established that the visual feedback did not modulate the strength of state-related PAC [3-way ANOVAs with factors Group (patient, controls), region (4 levels: PMC, M1, BA3, BA1&2) and feedback (2 levels: with or without visual feedback of tapping amplitude) for slow and fast tapping tasks]. The factor feedback showed neither an interaction nor main effects in either the slow [F(1,37) = 0.26, P = 0.616] or the fast tapping tasks [F(1,37) = 0.04, P = 0.840]. Therefore, in the following analysis, we pooled the two feedback conditions together. A three-way (group, task, and region) mixed ANOVA
