tests. In the analysis of healthy volunteers with personality profile data, raw TCI scores were properly processed (see Supplementary Information). To explore the association between the SNPs and phenotype, linear regression analyses were conducted, in which the endpoint TCI score (log transformed) and genotype data of each SNP were incorporated as dependent and independent variables, respectively. The correction of multiple tests for the analyses of the seven phenotypes was not performed in the present exploratory study. In the analysis of the post-mortem specimens for the expression analysis, the calculated expression level of the FAM119A (METTL21A) gene or CREB1 gene normalized to the ACTB gene for each sample was used. To explore the association between the SNPs and phenotype, Student's t-test or analysis of variance was performed, in which Bonferroni correction for multiple comparisons was used as the post hoc test. For these analyses, the relative expression level and genotype data of each SNP were incorporated as dependent and independent variables, respectively.
