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Chunk #35 — Discussion

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A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism.
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Consistent with Hypothesis 5, high LRs (needing fewer drinks for effects on the SRE) were related to more benign alcohol outcomes, perhaps because more feedback from fewer drinks might make it easier to stop drinking during an evening (Schuckit and Smith, 1996; Schuckit et al., 2007, 2008; Trim et al., 2013). On the other hand, a lower LR per drink (more drinks needed for effects on the SRE) was associated with both Problem Drinking and Abstinent Groups in Table 2. The relationship of LR to the Abstinent Group might reflect both the heavy drinking likely to contribute to the decision to stop consuming alcohol and the fact that LR is not closely related to impulsivity (Schuckit and Smith, 2017). Higher impulsivity is likely to interfere with treatment responses and to increase the probability of returning to heavier drinking (e.g., Littlefield et al., 2010). A lower number of drinks needed for effects (a higher LR per drink) might also have contributed to the greater ability of High-Risk Drinkers, compared to Problem drinkers, to avoid multiple alcohol problems. The contributions by LR