In preplanned assessments of the allelic variants likely to influence vulnerability to dependence on nicotine and other addictive substances, we focused on autosomal SNPs that provided convergent data with four additional abuser vs comparisons datasets; i.e. SNPs that a) display t values with p < 0.005 nominal significance in comparisons between European-American controls vs nicotine dependent research participants; b) identify genes that also display reproducibly-positive associations with addiction vulnerabilities in data from four other samples: i) NIDA African-American and European-American polysubstance abuser vs control comparisons based on 639,401 SNP comparisons with the requirement that both samples provide nominally significant results (p < 0.0025 for the joint probability) and clustering so that at least three such SNPs lay within 100 Kb of each other [31] ii) JGIDA (Japanese genetic investigations of drug abuse) Japanese methamphetamine abuser vs control comparisons, based on a requirement for nominal significance (p < 0.05) of SNPs lying within the same genes [56] (manuscript in preparation) and iii) COGA (Collaborative study on the genetics of alcoholism) alcohol dependent vs control comparisons, based on a requirement for nominal
