brain tissue during perinatal neurodevelopment and may lead to the onset of psychotic symptoms in early adulthood during the synaptic pruning process of the prefrontal cortex [43]. In early adulthood, animal models of neonatal hippocampal lesions show behavioral deficits comparable to schizophrenia symptoms and reveal neurobiological deficits in the prefrontal cortex [17, 39], suggesting prefrontotemporal disconnectivity in the pathophysiology of the disease.
