Meta-analyses of structural magnetic resonance imaging (sMRI) studies reveal gray matter volume deficits in different brain regions in schizophrenic patients. Affected regions are the medial temporal lobe including the hippocampus, the heteromodal association cortex including the prefrontal, anterior cingulate, superior temporal and parietal cortex as well as the thalamus. The degree of gray matter reduction is in the range of 5–10% in the frontotemporal and basal ganglia-thalamocortical network [10, 13, 16].
