Beside effects of environmental factors like cannabis abuse and trauma on cortical thickness in schizophrenia patients [19] or on reduced hippocampal volumes in patients and relatives with obstetric complications [8], schizophrenia susceptibility genes like neuregulin1 variants have shown impact on hippocampus volume [18], white matter density, and integrity in the anterior limb of the internal capsule [30]. A ZNF804A risk variant was associated with reduced cortical gray matter thickness in several regions [42].
