Using genotype data from the 1000 Genomes Project (Phase 1, March 2012 release), in African (YRI), East Asian (CHB + CHS + JPT) and European (CEU + FIN + GBR + IBS + TSI) populations, tagging the 1014 addiction-related genes (±20 kb) was performed in three rounds: (1) all markers with an MAF ≥ 0.05 were tagged at r2 ≥ 0.9 using Axiom-validated markers only; (2) remaining untagged markers were tagged at r2 ≥ 0.8 using Axiom-validated markers only; (3) any remaining untagged markers were tagged at r2 ≥ 0.9 using non-validated markers.
