Chunk #85 — STAR★METHODS — METHOD DETAILS — Estimation of Number of TS Genes — Maximum Likelihood Estimation

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De Novo Coding Variants Are Strongly Associated with Tourette Disorder.

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To estimate the fraction of damaging mutations carrying risk (E), we calculated M1 and M2, the observed rates of de novo damaging variants per TD proband and per SSC sibling control, respectively. More specifically, M1 = (199/484) and M2 = (180/602). We then estimated E as: E=(M1−M2)M1=0.273.