Chunk #86 — STAR★METHODS — METHOD DETAILS — Estimation of Number of TS Genes — Maximum Likelihood Estimation

Source

De Novo Coding Variants Are Strongly Associated with Tourette Disorder.

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For this calculation, we calculated E from unconfirmed counts (199 proband mutations, 180 SSC sibling mutations), as confirmation of the sibling de novo mutations was not attempted and we reasoned that both populations should have a similar rate of false positives.