We performed a similar estimate in the main text: we divided the difference in theoretical rate between probands and SSC sibling controls by the theoretical rate in probands. Using this approach, we estimated that 51.3% (95% CI 13.7 – 89.0%) of de novo LGD and 22.9% (95% CI 4.8 – 41.0%) of de novo damaging variants contribute risk to TD. However, we chose to estimate E using the first method to match work done by (Homsy et al., 2015).
