Since a large proportion of Tourette GWAS1 cases were derived from affected sib-pair families, which might be expected to harbor higher Tourette syndrome polygenic risk than cases from simplex families without affected first-degree relatives, we examined the relationship between ancestry-adjusted PRS (aPRS) in cases from multiplex (first-degree relative family-history positive) versus simplex (first-degree relative family-history negative) families (Supplemental Methods).
