As multiplex Tourette syndrome cases with a Tourette-affected parent or sibling (N=417) demonstrated similar mean aPRS to Tourette GWAS cases with a chronic tic-affected parent/sibling (N=111) (Fdf=1=0.12, p=0.73), we combined both Tourette case groups together for further analyses (Tourette/chronic tic family-history positive cases, N=528). The combined Tourette/ chronic tic multiplex cases had a significantly increased mean aPRS compared to aPRS from Tourette/ chronic tic simplex cases (N=346) (Fdf=1=4.90, p=0.027), confirming that multiplex cases were enriched for Tourette polygenic risk (Figure S7).
