The DUD liability-associated SNP rs11174811 was genotyped and the association with dependence on any illicit drug was tested. A male-specific significant relationship (p = .007) between dependence on any illicit substance and rs11174811 was detected. The frequency of the A allele was 14.9% in unaffected male subjects and 12.5% in affected male subjects. This association is thus in the direction opposite to that observed in the discovery study, where the frequency of the A allele was 15% and 22% in respective samples (Table 1). There was also a modest (p = .036) male-specific relationship between rs11174811 and perceived marital warmth.
