Chunk #18 — Results — The Discovery Study: CEDAR-SADS Sample — Candidate System Association Analysis — Spousal Relationship as a Mediator of the Association of AVPR1A with DUD
Family Assessment Measure score was associated with DUD in male subjects [p < .0001; OR (95% confidence interval) = 2.51 (1.80–3.50)] but not female subjects [p = .09; OR (95% confidence interval) = 1.37 (.96–1.95)]. In a linear regression model, with the genotype indexed in an additive fashion, the AVPR1A SNPs found above to be associated with DUD liability were also associated with FAM factor score in male subjects (p = .007) but not female subjects (p = .74). Given that this finding was obtained in an EA male sample, we decided to focus replication efforts in male EA samples.
