Chunk #17 — Results — The Discovery Study: CEDAR-SADS Sample — Candidate System Association Analysis — Spousal Relationship as a Mediator of the Association of AVPR1A with DUD
To test the mediational hypothesis, we used available data on the quality of spousal relationship, a human indicator for pair bonding, measured by the Dyadic Relationship Scale of the Family Assessment Measure (26). Figure 2 illustrates the best-fitting model tested. As can be seen in Figure 2, there are significant relationships between AVPR1A and FAM (p = .006), FAM and DUD (p < .001), and between AVPR1A and DUD risk (p = .006) in male subjects. The latter relationship is also mediated by FAM, as indicated by the significant indirect path (p = .013). This mediation is not complete, suggesting the involvement of additional factors in the highly significant relationship between AVPR1A and DUD liability. The alternative model, assuming DUD as mediator of the association between AVPR1A and FAM, demonstrated an equivalent fit.
