As can be seen from Table 1, three SNPs in the AVPR1A receptor gene, rs1587097 [p = .0003, odds ratio (OR) = 2.02 (1.37–3.00)], rs10784339 [p = .0008, OR = 1.72 (1.25–2.36)], and rs11174811 [p = .0008, OR = 1.72 (1.25–2.36)] generate the most significant results. In addition, these results are consistent across the genotypic and allelic tests. The results across the AVPR1A gene, including the allelic and sex-specific tests and the degree of LD between the SNPs, are presented in Figure 1. At the SNP level, no individual tests meet the strict Bonferroni correction threshold. The gene-wise permuted p value was 3 × 10−5. Whereas male and female subgroup tests yielded similar odds ratios, the relatively small female sample lacked power to yield a significant result at that effect size.
