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Chunk #11 — Methods — Statistical analysis

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The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences.
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We examined similar models independently including PRS for related conditions, BiP and MDD43,44, to determine the similarities and differences in developmental trajectories of EEG coherence for polygenic influences across all three conditions. Only the single most significant PRS were examined, selected on the basis of the EEG coherence association findings. All analyses were conducted in Matlab and were subject to an FDR correction for multiple testing; requiring p < 10–4 for significant associations based on an FDR less than 0.01.