We found that SCZ PRS were associated with increased EEG coherence in the theta and alpha frequencies in COGA participants. Findings for PRS based on the p < 0.05 threshold withstood a multiple test correction (FDR < 0.010), with the majority of coherence pairs in these frequency bands showing strong association with SCZ PRS (effect sizes ranged from 0.15 to 0.21 with all p-values < 10–4, Table 1; see also Fig. 2). We observed significant differences based on age and sex (Fig. 2 and Supplemental Figs. 1–6). Among males, the most robust associations were observed at ages 15–19 between PRS and high-alpha parietal-occipital (P4-O2 -- P3-O1), central-parietal (P7-P3 -- T7-C3, P8-P4 -- T8-C4, T7-P7 -- CZ-PZ, C3-P3 -- CZ-PZ), as well as right intrahemispheric (P8-P4--F8-F4, P8-P4--T8-C4) coherence pairs. Associations between PRS and high-alpha coherence were less robustly associated among females, with associations between PRS and fronto-central (F3-C3 -- F7-T7, FZ-CZ -- F8-T8) coherence pairs only observed at ages 24–26. Results are detailed in Table 1. In PRS-EEG coherence association models including alcohol, nicotine, and cannabis use frequency as covariates, results
