There was a clear association of ADHD PRS with ADHD case status, with similar differences in PRS between cases and controls observed for female individuals (OR [CI] = 1.57 [1.50–1.64], p = 4.1xE-91, mean R2 [SE] = .039 [.0034]) and male individuals (OR [CI] = 1.50 [1.46–1.53], p = 7.3xE-216, mean R2 [SE] = .032 [.0024]). In this analysis, several individual PGC studies did not show a significant association with case-control status in female individuals; this is likely due to low power (e.g., n = 27 female case/pseudocontrol pairs in the Canadian study).
