Results of meta-analyses of each leave-one-study/wave-out regression analysis for ADHD PRS are shown in Figure 4. There was no association of ADHD PRS with sex in cases (OR [confidence interval (CI)] = 1.02 [0.98–1.06], p = .28, mean R2 [SE] = .0019 [.00039]). Sensitivity tests were run excluding the data from 23andMe and non-European ancestry individuals and then also not including sex as a covariate in the discovery GWAS analyses; results remained similar (Supplemental Figure S7). There was no association of ADHD PRS with sex in controls (OR [CI] = 0.99 [0.96–1.01], p = .23, mean R2 [SE] = .0011 [.00024]) (Supplemental Figure S8). Mothers and fathers (in parent-offspring trio design studies) also did not differ in ADHD PRS (Supplemental Table S11).
