Five genetic variants at three loci, 4q23, 12q24 and 4q21, were significantly associated with UADT cancers in the independent replication series or after correction for multiple testing at a genome wide level in combined analysis (p≤5×10−7). The risk effects noted with all five variants were less prominent in the replication series when compared with the initial finding in the discovery series, consistent with the notion of “winner's curse” [17]. In combination we estimate these 5 variants are likely to explain only a small proportion (approximately 4%) of the UADT cancer familial risk.
