Chunk #13 — RESULTS — Heritability and polygenic scoring — Polygenic risk scoring in five independent cohorts. — Philadelphia Neurodevelopmental Cohort (PNC):

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Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.

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In the United States, participants were included from the PNC Study (N = 4201). We tested two phenotypes and found significant associations for both. We found that higher PRS for ASB were associated with symptom counts of both conduct disorder (p < 0.0001, delta R2 = 1.0%, Supplementary Table 11) and oppositional defiant disorder (p < 0.0001, delta R2 = 0.4%, Supplementary Table 12).