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Chunk #82 — III. Selected Methodological Issues — A. Genotyping using pooled DNAs

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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Here, we provide assessment of several of the steps necessary to validate and characterize features of the power and sensitivity of multipool genome scanning strategies. Used with high densities of genomic markers, carefully-performed multiple pool studies can 1) provide increased study feasibility and 2) preserve virtually absolute genetic confidentiality with 3) only modest effects on the sensitivity and specificity of genome wide association.