We also considered the consistency of our results with previous BD GWA studies. There have been three previous GWA studies of BD (13, 15, 16), in addition to a more recent collaborative GWA meta-analysis study (17), a subset of which were represented in the previous independent GWA studies. The Ferreira et al. (2008) collaborative GWA meta-analysis study (17) identified a region of strong association in ANK3, apparently distinct from that detected in Baum et al. (2008). Ferreira et al. also found new evidence for association at 15q14, which is near C15ORF53, as well as further support for the previously reported CACNA1C gene; these authors concluded that ion channelopathies may be involved in the pathogenesis of BD.
