We sought to replicate our most strongly associated SNPs in two independent sets of subjects, one family-based, and one case-control. Positive results were seen with rs1495186 in C15ORF53 and some additional SNPs in that region. When considered cumulatively via meta-analysis with the primary EA sample, these results demonstrate consistent support for association of SNPs in the C15ORF53 region with BD, and provide additional supportive evidence of association in other regions.
