Using proxies with r2≥0.8 in 1000 Genomes Europeans, we queried the GWAS catalogue [38] (P ≤ 5 × 10−8) for pleiotropic effects of our novel sentinel SNVs. Two, rs11539157 and rs3001723 were previously associated with schizophrenia [36], suggesting shared biological pathways between schizophrenia and smoking behaviours (Table 2). This fits with the known association of smoking with schizophrenia [51]. Two, rs1514175 and rs2947411 have previously been associated with BMI [52], and extreme obesity [53].
