eQTL lookups in GTEx V7 (13 Brain tissues with ≥80 samples) [39], Brain xQTL [40] and BRAINEAC [41] databases revealed that the A allele at rs462779, which decreases risk of smoking initiation, also decreased expression of REV3L in cerebellum in GTEx (A allele P = 4.8x10-8; β = −0.40) and was in strong LD with the top eQTL for REV3L in cerebellum (r2 = 0.86 with rs9487668 in 1000 Genomes Europeans). The smoking initiation-associated SNV, rs12780116, was an eQTL for BORCS7 in four brain tissues, and NT5C2 in the cerebellar hemisphere (A allele P = 4.5 × 10−7; β = −0.32) and the cerebellum (P = 5.6 × 10−6; β = −0.415; in strong LD with the top eQTL, r2 = 0.97 with rs11191546). The G allele of a second variant in the region, rs7096169 (intronic to BORCS7 and only in weak LD with rs12780116, r2 = 0.18 in 1000G Europeans) increases smoking initiation and reduces expression of BORCS7 and AS3MT in eight brain tissues (including dorsolateral prefrontal cortex in the Brain xQTL and was the top BORCS7 eSNP in
