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Chunk #20 — Results — Statistical analysis of pooled data — Polygenic score based analysis

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Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
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Genotype scores derived from each half of the German GWAS sample differed significantly between patients and controls of the respective remaining half (p=1.28E–6 and p=9.66E–9), and genotype scores derived from the total German sample differed between patients and controls in the COGA (p=3.92E–2) as well as in the SAGE (p=1.13E–4) sample (scores based on ∼ 84,000 SNPs).