Two further SNPs located around ADH1C showed p<1E–5 in the present study and yielded nominal significance with the same allele in the COGA sample. These were rs1372679 (p=1.61E–6, OR=1.48; pCOGA=3.53E–2, ORCOGA=1.33), and rs4699748 (p=2.51E–7, OR=1.49; pCOGA=4.66E–2, ORCOGA=1.28; Table 2). The SNP rs9825310 (p=7.55E–6, OR=1.25), which is located near GPD1L on chromosome 3p22.3, also showed nominally significant association with the same allele in the COGA sample (pCOGA=2.95E–3, ORCOGA= 1.28). An analysis was performed to test for association in our GWAS for the top SNPs (p<1E–5) reported by the COGA (Edenberg, Koller, Xuei et al. 2010) and SAGE (Bierut, Agrawal, Bucholz et al. 2010) GWAS. This yielded no significant results.
