Chunk #44 — Methods — Variance of gene expression

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Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.

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To assess the genetic contribution to the variance in human cerebellar gene expression, we first determined between-subject variance, as a percentage of the total variance in probe expression, using ICC [31] for 15 samples measured in replicate on 5–6 different plates and 2–3 different days.