Using multivariable linear regression models, we then calculated the proportion of variance in cerebellar gene expression levels that were explained by technical effects (PCR plate, RIN, (RIN-RINmean)2), biological covariates (APOE ε4 dosage, age at death, gender) and the “best” cisSNP for each probe. These analyses were carried out on the combined dataset consisting of cerebellar expression measurements from 374 subjects and 15,283 probes with at least one cisSNP (Text S1).
