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Chunk #9 — Online Methods: — Testing cohort

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Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
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A sensitivity analysis was performed by removing one individual from each pair of related individuals (third-degree or closer; kinship coefficient > 0.0442), confirming similar results within this subpopulation comprised of 222,529 of the 288,978 (77%) testing dataset participants (Supplementary Table 10).