Although many studies have collectively suggested the involvement of a large number of genes in human alcohol use disorders (AUDs) (Palmer et al., 2012), few genes have been unambiguously associated with alcohol dependence or other aspects of alcohol abuse. The fruit fly Drosophila melanogaster—which exhibits behavioral responses to ethanol that mirror those observed in mammals (Devineni et al., 2011; Scholz et al., 2000)—has been used to identify candidate genes for subsequent studies on AUDs in humans and for directly testing the roles of genes implicated by human studies (Rodan and Rothenfluh, 2010; Scholz and Mustard, 2011). The advent of transposon-mediated mutagenesis and transgenesis (Rubin and Spradling, 1982) greatly facilitated the use of the fly model to investigate genes that influence many biological processes including behavioral responses to ethanol (Bellen et al., 2011; Bellen et al., 2004; Rodan and Rothenfluh, 2010). For example, studies using transgenic flies have demonstrated that signaling via cyclic AMP, monoamines, insulin, and neuropeptides impact ethanol-related behaviors (Bainton et al., 2000; Corl et al., 2005; Moore et al., 1998; Rodan et al., 2002; Scholz, 2005; Wen et
