The results of this study are in line with results from recent GWAS, indicating associations of CADM2 with substance use and abuse (including alcohol consumption, lifetime cannabis use, and general drug experimentation), 1 , 17 , 23 , 49 sexual risk behavior (such as age at first sexual intercourse and number of sexual partners), 17 , 28 and different aspects of self‐control (sensation seeking, hyperactivity, and risk‐taking propensity). 1 , 18 , 23 , 25 Our study finds support for these findings in a large, hypothesis‐driven, multi‐cohort and phenome‐wide study for risk behavior, indicating that the role of CADM2 in risky behaviors and reduced self‐control is robust. This is also in line with some earlier reported genetic correlations for various forms of risky behaviors, 40 suggesting overlapping genes directly or indirectly influence these behaviors. The observed mediation effect of risk‐taking proneness is in line with previous suggestions that the association between substance use and CADM2 might be (partially) mediated by reduced self‐control. 49 Our results suggest that variability in CADM2 may give rise to various aspects of reduced self‐control underlying
