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Chunk #32 — DISCUSSION

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Associations between the CADM2 gene, substance use, risky sexual behavior, and self-control: A phenome-wide association study.
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proneness is in line with previous suggestions that the association between substance use and CADM2 might be (partially) mediated by reduced self‐control. 49 Our results suggest that variability in CADM2 may give rise to various aspects of reduced self‐control underlying multiple expressions of risky behavior. This corresponds with proposed shared genetic and neurobiological mechanisms underlying various risky behaviors. 14 , 15