CADM2 is mainly expressed in the brain (predominantly prefrontal and anterior cingulate cortices [PFC and ACC]), the central nervous system, and its peripheral nerve fibers. 23 , 50 The PFC and ACC are generally involved in cognitive functions concerned with motivation and controlling behavior. 51 The ACC has been associated with error detection and response inhibition, whereas several regions within the PFC are involved in reward learning and decision‐making processes, which can all be linked to self‐control and risky behavior. 52 , 53 , 54 By affecting brain functions in these regions, variation in CADM2 may result in different manifestations of reduced self‐control and risky behavior. Future research could further delineate which neurobiological mechanisms are involved in the link between CADM2, reduced self‐control, and risky behaviors.
