In summary, DSM-5 cannabis use disorder is a highly prevalent, comorbid, disabling disorder that often goes untreated. Numerous risk factors were identified that could stimulate further studies of differences in correlates of DSM-5 cannabis use disorder by sex, age and race/ethnicity, and inform additional hypothesis-driven studies. Most importantly, this study highlighted the urgency of identifying and implementing effective prevention methods. The study also highlights the need to educate the public, professionals and policymakers about the seriousness of cannabis use disorder, and for public health efforts to destigmatize and encourage help-seeking for cannabis use disorder among those who cannot reduce their use of marijuana on their own, despite substantial harm to themselves and others.