weeks of abstinence, ↓ working memory until 3 weeks of abstinence,↓ attention after 1 month of abstinence (Hanson et al. 2010)↓ White matter volume associated with more depression symptoms (Medina et al. 2007a, b)= Hippocampal volumes as controls (Medina et al. 2007a, b)↑ Response in parietal but ↓ in dorsolateral prefrontal and occipital cortices during spatial working memory after 1 month of abstinence (Schweinsburg et al. 2008)↓ Performance on attention, working memory, and speeded processing tasks associated with ↓ FA (Bava, et al. 2010a, b) ↑ Response in superior prefrontal and insula regions during spatial working memory after 2 -7 days of abstinence (Schweinsburg et al. 2010b).↑ Response most prefrontal and medial frontal regions, but ↓ Response in inferior frontal and temporal regions during spatial working memory after >2 days of abstinence (Schweinsburg 2005a, b) SCR superior corona radiata; ILF inferior longitudinal fasciculus; FOF fronto-occipital fasciculus; CC corpus callosum; SLF superior longitudinal fasciculus; CR corona radiata; FA fractional anisotropy; PFC prefrontal cortex; IQ intelligence quotient
