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Chunk #25 — Methods — Analysis Plan — Developmentally-Informative GWAS

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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency.
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For the GWAS in each developmental period (U12-17, U18-25, U26+), paths were estimated from each SNP to the corresponding model component. Genetic correlations were calculated between the components of the genomic structural equation model and a set of other phenotypes with publicly available GWAS summary statistics (Neale Lab 2018; Walters et al. 2018; Karlsson Linnér et al. 2019, 2020; Sanchez-Roige et al. 2019; Howard et al. 2019; Purves et al. 2020; Okbay et al. 2022; Saunders et al. 2022) using LDSC. A list of the phenotypes with sample sizes and citations is included in Table S3.