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Chunk #30 — Methods — Measurements and data analysis — 2. Data reduction - calculation of spectral coherence variables

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The relationship of Asperger's syndrome to autism: a preliminary EEG coherence study.
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Approximately 8 to 20 minutes of awake state, artifact free, EEG data per subject were transformed by use of BESA software, to the scalp Laplacian or current source density (CSD) estimates for surface EEG studies. The CSD technique was employed as it provides reference independent data that are primarily sensitive to underlying cortex and relatively insensitive to deep/remote EEG sources, and minimizes the effect of volume conduction on coherence estimates by emphasizing sources at smaller spatial scales than unprocessed potentials. This approach obviates coherence contamination from reference electrodes and minimizes contaminating effects from volume conduction [30,50].